The PCM-3000 pH and Conductivity Monitor is ideal for accurate on-line pH and conductivity monitoring of HPLC applications. It is an upgrade for all UV-vis detector variants of the UltiMate® 3000 system platform, including the Diode Array, Multiple Wavelength, and Variable Wavelength Detectors. The PCM-3000 can be used for monitoring the gradient formation in salt- or pH-gradient-based ion-exchange chromatography (IEC), typically used for biopharmaceutical analysis.
IEC is a versatile separation technique for profiling the charge heterogeneity of biotherapeutic proteins, including monoclonal antibodies (MAbs). The elution can be driven by pH, ionic-strength, or a combination of these two parameters. The PCM-3000 supports all modes of chromatography and provides verification of the elution conditions, the retention behavior of the sample, and the precision and repeatability of the instrumentation.
- Simultaneous pH and conductivity monitoring with wide dynamic ranges
- Wide flow rate range (up to 100 mL/min)
- Low-volume flow cells for short response times and good compatibility with low flow rates
- Best accuracy through temperature compensation of conductivity and pH results
- Upgrade to UltiMate 3000 system UV-vis detectors
- Full integration into the UltiMate 3000 system platform
- Cost-effective, plug-and-play device
| Conductivity |
|---|
| Range: | 1 μS/cm–1 S/cm |
| Accuracy: | ±2% of full scale
calibration range (1 μS–100 mS/cm,
1-point calibration or 1 μS–200 mS/cm,
2-point calibration) or ±10 μS/cm,
whichever is greater |
| Flow Cell Constant: | 50 /cm (±20 /cm) |
| Max Flow Rate: | 100 mL/min |
| Max Pressure: | 5 MPa (50 bar, 725 psi) |
| Flow Cell Volume: | 21 μL (fitting to fitting,
active volume is 2 μL) |
| Temp. Range: | +4 °C to +50 °C (liquid) |
| Wetted Parts: | PEEK™ and titanium |
| Temp. Compensation: | Yes |
| pH |
|---|
| Range: | pH 0–14 (specifications valid between pH 2–12) |
| Accuracy: | 20–30 °C: ±0.1 pH, 30–40 °C: ±0.35 pH |
| Drift: | max 0.1 pH units deviation/10 h |
| Flow Cell Volume: | 28 μL (fitting to fitting) |
| Max Flow: | 100 mL/min |
| Max Pressure: | 0.7 MPa (7 bar, 102 psi) |
| Temp. Range: | +4 °C to +50 °C (liquid) |
| Wetted Parts: | PEEK, epoxy, glass, HDPE, EPDM |
| Temp. Compensation: | Yes |
| General Specifications |
|---|
| Dimensions: | (h × w × d):
18 × 14 × 29 cm (separate unit)
18 × 11 × 22 cm (mounted to detector) |
| Weight: | 1.5 kg |
| Power Requirements: | 5 V DC, max. 1.5 W (provided internally by DAD/MWD/VWD) |
The pH and Conductivity Monitor PCM-3000 is shipped with pH and conductivity flow cell and a pH electrode.
| Hardware |
|---|
| PCM-3000 UltiMate 3000 pH and Conductivity Monitor for the use with DAD-3000 and MWD-3000 |
6082.2000 |
| PCM-3000 UltiMate 3000 pH and Conductivity Monitor for the use with VWD-3x00 |
6082.2005 |
| Related UV-vis Detectors |
|---|
| DAD-3000 - UltiMate 3000 Diode Array Detector (Without Flow Cell) |
5082.0010 |
| DAD-3000RS - UltiMate 3000 Rapid Separation Diode Array Detector (Without Flow Cell) |
5082.0020 |
| MWD-3000 - UltiMate 3000 Multiple Wavelength Detector (Without Flow Cell) |
5082.0030 |
| MWD-3000RS - UltiMate 3000 Rapid Separation Multiple Wavelength Detector (Without Flow Cell) |
5082.0040 |
| VWD-3100 - UltiMate 3000 Single Channel Variable Wavelength Detector (Without Flow Cell) |
5074.0005 |
| VWD-3400RS - UltiMate 3000 Rapid Separation Four Channel Variable Wavelength Detector (Without Flow Cell) |
5074.0010 |
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