RSLC and x2-Dual Provide Fast, Flexible Performance

Pharmaceutical drug discovery identifies, validates and optimizes drug candidates based on achieving a desired pharmacological activity. However, at this point, there is very little data on the New Chemical Entity’s (NCE) safety. Research in the pre-clinical drug development area allows us to understand much about the safety of the compound by investigating how a compound affects the body and how the body affects the compound. Performing both in-vitro and in-vivo studies, an over-arching safety profile is constructed. Clearly, creating this profile involves a very large number of highly sensitive analyses.

Dionex solutions, based on the UltiMate^® RSLC and x2 Dual systems, have the sensitivity and throughput required to handle limited samples in large numbers.

RSLC System Solutions Keep Up with Demanding Sample Loads

Dionex RSLC system solutions offer both high resolution and high speed. Designed for small particle columns, chromatographic methods can be optimized for shortest analysis time while maintaining high resolution.

The x2 Dual systems provide the throughput of two HPLC systems while occupying the bench space of only one. Configurable in either parallel or tandem arrangements, the x2 Dual is the answer for demanding sample loads found in pre-clinical development.

Dionex Offers State-of-the-Art UV Absorbance Detection

State-of–the-art in liquid chromatography demands speed, selectivity and sensitivity. The RSLC line of system solutions offers both variable wavelength and diode array detectors specifically designed for the fast UHPLC separations. With scan rates of up to 100Hz, these detection systems can produce data points and/or scans sufficient to produce accurate and precise quantitation.

Chromeleon – Secure, Reliable Data

In gathering data leading up to Investigational New Drug submission, dependable data is paramount. Chromeleon^®’s built-in security features not only provide GLP compliance but also meet the rigorous requirements for regulatory compliance such as audit trails, electronic signatures, and data files with imbedded metadata.