The OmniPac® PAX-500 column is a macroporous, low-capacity, solvent-compatible column designed to separate anionic and neutral species in a single run. This column combines both anion-exchange and polymeric reversed-phase retention mechanisms in a single column. Good for the simultaneous separation of neutral and anionic species Unique selectivity for polar and ionic organic analytes Effective for biological samples such as purines, pyrimidines, and vitamins Good for drugs and pharmaceuticals
The multimode separation mechanism of the OmniPac PAX-500 is achieved by coating a macroporous, hydrophobic core for reversed-phase retention, with an anion-exchange latex bead layer for anion-exchange retention. The macroporous structure provides an accessible hydrophobic core where reversed-phase retention occurs. The anion-exchange selectivity is provided by an anion-exchange MicroBeadTM latex that coats the hydrophobic core. Since the anion-exchange layer is identical to that of the OmniPac PAX-100, the two columns exhibit similar ion-exchange selectivity. As a result, the OmniPac PAX-100 can be used to develop the ion-exchange separation and the method can then be transferred to the OmniPac PAX-500 for refinement to include the reversed-phase separation. The OmniPac PAX-500 column is 100% solvent compatible and should always be run with at least 1% organic solvent in the mobile phase to maintain column life. The OmniPac PAX-500 may be used for the separation of compounds such as alcohols, alkanolamines, antihistamines, anti-inflammatory agents, aromatic acids, inorganic acids, peptides, purines and pyrimidines, sulfonamides, sulfonated anionic surfactants, and water-soluble vitamins.
|
